Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374211 | 0.89 | SLC9A3 (0.35) | NPC1SLC9A3RORCHTR2AKMT2A | |
| SCHEMBL1799220 | 0.82 | ADAMTS7 (0.45) | NPC1SLC9A3RORCMMP1MMP13 | |
| SCHEMBL1799218 | 0.82 | ADAMTS7 (0.45) | NPC1SLC9A3RORCMMP1MMP13 | |
| SCHEMBL4372629 | 0.78 | PKM (0.41) | KMT2AMEN1MMP1MMP13ALDH1A1 | |
| SCHEMBL4288103 | 0.75 | MMP3 (0.41) | KMT2AMEN1MMP1MMP13ALDH1A1 | |
| SCHEMBL4288106 | 0.75 | MMP3 (0.41) | KMT2AMEN1MMP1MMP13ALDH1A1 | |
| SCHEMBL3875819 | 0.74 | SLC9A3 (0.41) | NPC1SLC9A3ALDH1A1RAB9A | |
| SCHEMBL4376127 | 0.72 | L3MBTL1 (0.39) | MMP1MMP13 | |
| SCHEMBL1800636 | 0.69 | ADAMTS7 (0.48) | MMP1MMP13 | |
| SCHEMBL1800637 | 0.69 | ADAMTS7 (0.48) | MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |