Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GPX4 | P36969 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327065 | 0.85 | CHRM2 (0.38) | PTGS1PTGS2PTPN1 | |
| SCHEMBL3523911 | 0.75 | TSHR (0.49) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL2545519 | 0.72 | MEN1 (0.42) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL20266539 | 0.72 | TRPM8 (0.44) | PTGS1PTGS2ALDH1A1HPGDLMNA | |
| SCHEMBL7447573 | 0.70 | SMN1; SMN2 (0.50) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL1642239 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTGAAHPGDLMNA | |
| SCHEMBL2176096 | 0.70 | MTNR1A (0.41) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL25541795 | 0.69 | ADRA2A (0.49) | PTGS1PTGS2PTPN1NPC1RAB9A | |
| SCHEMBL27818397 | 0.69 | PTPN1 (0.59) | PTPN1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4326713 | 0.69 | TRPM8 (0.48) | NPC1RAB9AALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097384-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | AstraZeneca AB (SE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008063116-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |