Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17419222 | 0.65 | — | — | |
| SCHEMBL28542927 | 0.64 | GCGR (0.62) | GCGRNPC1RAB9A | |
| SCHEMBL15243172 | 0.56 | TDO2 (0.43) | JAK2JAK1TYK2JAK3PSMB5 | |
| SCHEMBL42781 | 0.53 | PTGDR2 (0.48) | — | |
| SCHEMBL3795015 | 0.52 | CHRNB2 (0.55) | GCGRNPC1RAB9A | |
| SCHEMBL22732970 | 0.51 | DAO (0.50) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL31314522 | 0.51 | DAO (0.45) | GCGRNPC1RAB9AKDM4EMAPT | |
| SCHEMBL126782 | 0.51 | PTGDR2 (0.50) | GCGR | |
| SCHEMBL31240954 | 0.51 | HTR2C (0.52) | PSMB5 | |
| SCHEMBL779938 | 0.50 | CHRNB4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135973-A1 | METHOD FOR TREATING CHRONIC PAIN | SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE (US) | 2012-05-31 | — | — | US | claimed |
| WO-2012033916-A1 | METHOD FOR TREATING CHRONIC PAIN | SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE (US) | 2012-03-15 | — | — | WO | claimed |
| US-20140073619-A1 | METHOD FOR TREATING CHRONIC PAIN | SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE (US) | 2014-03-13 | — | — | US | disclosed |
| US-20120135973-A1 | METHOD FOR TREATING CHRONIC PAIN | SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE (US) | 2012-05-31 | — | — | US | disclosed |
| WO-2012033916-A1 | METHOD FOR TREATING CHRONIC PAIN | SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135973-A1 | METHOD FOR TREATING CHRONIC PAIN | OPRK1, TRPV1, OPRM1 | GCGR 4450/4885JAK2 4185/4885JAK1 4805/4885 |
| US-20140073619-A1 | METHOD FOR TREATING CHRONIC PAIN | OPRK1, TRPV1, OPRM1 | GCGR 4450/4885JAK2 4185/4885JAK1 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.