Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4544051 | 1.00 | HRH3 (0.45) | HRH3SCN1ASCN2ASCN3AACHE | |
| SCHEMBL13787355 | 0.89 | HRH3 (0.51) | HRH3ACHEHRH2HRH1 | |
| SCHEMBL4543504 | 0.86 | HRH3 (0.49) | HRH3ACHEHRH2HRH1 | |
| SCHEMBL4543507 | 0.86 | HRH3 (0.49) | HRH3ACHEHRH2HRH1 | |
| Fumaric Acid SCHEMBL4383647 | 0.83 | HRH3 (0.69) | HRH3SCN1ASCN2ASCN3AACHE | |
| Fumaric Acid SCHEMBL4383653 | 0.83 | HRH3 (0.69) | HRH3SCN1ASCN2ASCN3AACHE | |
| Fumaric Acid SCHEMBL4383651 | 0.83 | HRH3 (0.69) | HRH3SCN1ASCN2ASCN3AACHE | |
| Fumaric Acid SCHEMBL4562984 | 0.78 | HRH3 (0.49) | HRH3ACHEHRH1 | |
| Fumaric Acid SCHEMBL4562985 | 0.78 | HRH3 (0.49) | HRH3ACHEHRH1 | |
| SCHEMBL4394487 | 0.71 | HRH3 (0.84) | HRH3ACHEHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181948-A1 | DIAMINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1847530-A1 | DIAMINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181948-A1 | DIAMINE DERIVATIVE | ARG1, PRMT5, PRMT1 | HRH1 547/4885HRH3 452/4885SCN1A 4418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.