Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 7/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.36 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375486 | 0.92 | MAPK1 (0.36) | AKT1MAPK1ALDH1A1 | |
| SCHEMBL4543472 | 0.92 | MAPK1 (0.37) | ULK1AKT1MAPK1 | |
| SCHEMBL4544087 | 0.91 | AKT1 (0.39) | ULK1AKT1MAPK1 | |
| SCHEMBL14114961 | 0.82 | AKT1 (0.42) | ULK1AKT1MAPK1ULK2MKNK2 | |
| SCHEMBL1529698 | 0.82 | AKT1 (0.42) | ULK1AKT1MAPK1ULK2MKNK2 | |
| SCHEMBL1530043 | 0.80 | ULK1 (0.38) | ULK1AKT1MAPK1ULK2MKNK2 | |
| SCHEMBL1530041 | 0.80 | ULK1 (0.38) | ULK1AKT1MAPK1ULK2MKNK2 | |
| SCHEMBL4376938 | 0.80 | ALDH1A1 (0.44) | ULK1AKT1MAPK1ALDH1A1 | |
| SCHEMBL4541583 | 0.76 | ITGB1 (0.38) | ULK1AKT1MAPK1ULK2ITGB1 | |
| SCHEMBL4540065 | 0.76 | AKT1 (0.45) | AKT1MAPK1ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |