Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13970537 | 0.91 | LMNA (0.70) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL4548341 | 0.87 | LMNA (0.81) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL29530815 | 0.87 | LMNA (0.81) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL19272079 | 0.80 | LMNA (0.68) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL15581521 | 0.79 | PKM (0.52) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL4545199 | 0.79 | LMNA (0.49) | LMNAPKMALDH1A1KMT2AMEN1 | |
| Acetosyringone SCHEMBL15511 | 0.78 | LMNA (1.00) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL13851422 | 0.78 | CA12 (0.70) | LMNAPKMCA12CA1CA2 | |
| SCHEMBL15698190 | 0.78 | TNKS2 (0.60) | LMNATNKS2PDE4APDE4BPDE4C | |
| SCHEMBL14732689 | 0.78 | LMNA (0.55) | LMNAPKMALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962600-B2 | Neuroprotective compounds and their use | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20120108549-A1 | NEUROPROTECTIVE COMPOUNDS AND THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108549-A1 | NEUROPROTECTIVE COMPOUNDS AND THEIR USE | NLN, ATP6V1B2, BDNF | LMNA 653/4885PKM 2960/4885CA12 4580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.