Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622150 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL28158867 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL2449598 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL6836877 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL16967925 | 0.80 | LMNA (0.36) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL18726773 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL11417303 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL5641654 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL15804810 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAALDH1A1HSD17B10NPC1 | |
| SCHEMBL4185553 | 0.75 | SETD7 (0.43) | SMN1; SMN2LMNAALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358092-B1 | 2-AZA-4-(ALKOXYCARBONYL)SPIRO-(4,5)DECAN-3-ONE | LONZA A.G. (CH) | 1991-12-11 | — | — | EP | claimed |
| US-11603368-B2 | Fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2023-03-14 | — | — | US | disclosed |
| US-11492347-B2 | Fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2022-11-08 | — | — | US | disclosed |
| CN-113181924-A | High-strength dehydrogenation catalyst and preparation method and application thereof | 万华化学集团股份有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-106928038-B | Method for preparing cyclohexanone by oxidizing cyclohexanol with hydrogen peroxide at normal temperature | 江苏工程职业技术学院 | 2021-04-06 | — | — | CN | disclosed |
| CN-106892805-B | Synthesis method of 4- (4-hydroxyphenyl) cyclohexanone | 西安瑞联新材料股份有限公司 | 2021-02-23 | — | — | CN | disclosed |
| CN-212467604-U | Cyclohexanone air compressor machine residual gas collection device | 山西潞宝兴海新材料有限公司 | 2021-02-05 | — | — | CN | disclosed |
| EP-3749659-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO Pharma (FR) | 2020-12-16 | — | — | EP | disclosed |
| EP-3749658-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO Pharma (FR) | 2020-12-16 | — | — | EP | disclosed |
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-26 | — | — | US | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| EP-0358092-B1 | 2-AZA-4-(ALKOXYCARBONYL)SPIRO-(4,5)DECAN-3-ONE | LONZA A.G. (CH) | 1991-12-11 | — | — | EP | disclosed |
| EP-0219199-B1 | METHOD FOR PREPARATION OF LACTONES | COULSTON INTERNATIONAL CORPORATION (US) | 1991-07-31 | — | — | EP | disclosed |
| EP-0358092-A1 | 2-Aza-4-(alkoxycarbonyl)spiro-(4,5)decan-3-one | LONZA A.G. (CH) | 1990-03-14 | — | — | EP | disclosed |
| US-4772728-A | AND ALDEHYDE | ANGUS CHEMICAL COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0219199-A1 | Method for preparation of lactones | COULSTON INTERNATIONAL CORPORATION (US) | 1987-04-22 | — | — | EP | disclosed |
| US-4496762-A | Process for the preparation of N-(2-(cyclo-hexen-1-yl)ethyl)-4-methoxybenzeneacetamide | EASTMAN KODAK COMPANY (US) | 1985-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | SMN1; SMN2 4008/4885LMNA 4703/4885ALDH1A1 2143/4885 |
| US-11492347-B2 | Fused thiophene derivatives and their uses | FTH1, SLC40A1, FECH | SMN1; SMN2 4008/4885LMNA 4703/4885ALDH1A1 2143/4885 |
| US-11603368-B2 | Fused thiophene derivatives and their uses | FTH1, SLC40A1, FECH | SMN1; SMN2 4008/4885LMNA 4703/4885ALDH1A1 2143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.