Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19172568 | 0.97 | KEAP1 (0.47) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL13411696 | 0.91 | KEAP1 (0.44) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL4545267 | 0.91 | — | — | |
| SCHEMBL19171419 | 0.89 | EPHX1 (0.58) | KEAP1NFE2L2KMT2AEPHX1KDM4E | |
| SCHEMBL4390993 | 0.89 | KDM4E (0.52) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL11382117 | 0.88 | KEAP1 (0.55) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL13466509 | 0.88 | KEAP1 (0.61) | KEAP1NFE2L2KMT2AEPHX1KDM4E | |
| SCHEMBL9379381 | 0.87 | KEAP1 (0.41) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL19171562 | 0.87 | KEAP1 (0.41) | KEAP1NFE2L2KMT2AMTNR1AEPHX1 | |
| SCHEMBL19171946 | 0.85 | EPHX1 (0.61) | KEAP1NFE2L2KMT2AEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170210736-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2017-07-27 | — | — | US | disclosed |
| US-9156125-B2 | Polishing pad with light-stable light-transmitting region | CABOT MICROELECTRONICS CORPORATION (US) | 2015-10-13 | — | — | US | disclosed |
| US-20130273813-A1 | POLISHING PAD WITH LIGHT-STABLE LIGHT-TRANSMITTING REGION | CABOT MICROELECTRONICS CORPORATION (US) | 2013-10-17 | — | — | US | disclosed |
| US-20120108741-A1 | AMBIENT-TEMPERATURE SELF-CURABLE AND FLUORINE CONTAINING AQUEOUS-BASED POLYURETHANE (PU) DISPERSION AND METHOD OF MANUFACTURING THE SAME AND ITS MODIFIED COATED FILM APPLICATIONS | Chou, Tai-Chang (TW) | 2012-05-03 | — | — | US | disclosed |
| US-4298747-A | FINISHING AGENTS FOR TEXTILES CONTAINING CELLULOSE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1981-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210736-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | NHERF1, SLC9A3, SLC26A3 | KEAP1 1087/4885NFE2L2 1616/4885KMT2A 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.