Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 12/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 12/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 11/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 5/20 | 1.00 |
| ▸ | DRD4 | P21917 | 5/20 | 1.00 |
| ▸ | HRH2 | P25021 | 5/20 | 1.00 |
| ▸ | HTR7 | P34969 | 5/20 | 1.00 |
| ▸ | HRH1 | P35367 | 5/20 | 1.00 |
| ▸ | HTR2A | P28223 | 4/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | HTR5A | P47898 | 3/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 2/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8553731 | 0.93 | HTR1A (0.87) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| Fumaric Acid SCHEMBL8558915 | 0.93 | HTR1A (0.87) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL14768598 | 0.88 | HTR1A (0.78) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL4546517 | 0.87 | HTR1A (0.77) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL4546542 | 0.85 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL16510265 | 0.85 | HTR1A (0.74) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL8595342 | 0.85 | HTR1A (0.74) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL8599103 | 0.83 | HTR1A (0.71) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL8595084 | 0.83 | HTR1A (0.71) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL4546508 | 0.80 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168786-B2 | 1,2,4-triazole- 3,5-dione derivatives; for imaging and therapy of psychiatric, eating, sleeping, bipolar disorder; anxiolytic agent, antidepressant; Alzheimer's, Parkinson's diseases, epilepsy; imaging agents for a serotonin receptor | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-05-01 | — | — | US | disclosed |
| US-20080138283-A1 | Radiolabeled compounds and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080138283-A1 | Radiolabeled compounds and uses thereof | HTR5A, SLC18A2, HTR1A | HTR1A 3/4885ADRA1A 221/4885ADRA1B 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.