Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CFD | P00746 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45473 | 1.00 | HTT (0.55) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL44802 | 0.86 | TAS1R3 (0.65) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL44803 | 0.86 | TAS1R3 (0.65) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL15432711 | 0.86 | LMNA (0.65) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL16923854 | 0.85 | PDE2A (0.50) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL40433 | 0.84 | ALDH1A1 (0.52) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL40217 | 0.84 | ALDH1A1 (0.52) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL44987 | 0.83 | KMT2A (0.52) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL40131 | 0.83 | CTSS (0.52) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL40168 | 0.83 | KMT2A (0.52) | HTTTAS1R3TAS1R1TAS1R2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |