Sugi Predict

Sugi Predict / Compounds / SCHEMBL4548028

SCHEMBL4548028

SCHEMBL4548028

Cn1nc(C(F)(F)F)cc1-c1cccs1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 0.58
▸ ALDH1A1 P00352 7/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ RAB9A P51151 5/20 0.52
▸ NPC1 O15118 4/20 0.52
▸ HDAC3 O15379 1/20 0.51
▸ HDAC4 P56524 1/20 0.51
▸ HDAC1 Q13547 1/20 0.51
▸ HDAC7 Q8WUI4 1/20 0.51
▸ HDAC2 Q92769 1/20 0.51
▸ HDAC10 Q969S8 1/20 0.51
▸ HDAC11 Q96DB2 1/20 0.51
▸ HDAC8 Q9BY41 1/20 0.51
▸ HDAC6 Q9UBN7 1/20 0.51
▸ HDAC9 Q9UKV0 1/20 0.51
▸ HDAC5 Q9UQL6 1/20 0.51
▸ MAPK1 P28482 2/20 0.47
▸ GAA P10253 1/20 0.47
▸ HPGD P15428 3/20 0.45
▸ HTT P42858 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4548038 0.91 KDM4E (0.51) KDM4EALDH1A1L3MBTL1RAB9ANPC1
SCHEMBL27423832 0.86 ALDH1A1 (0.46) KDM4EALDH1A1L3MBTL1RAB9ANPC1
SCHEMBL18195118 0.82 KDM4E (0.55) KDM4EALDH1A1L3MBTL1RAB9ANPC1
SCHEMBL16487838 0.77 PTGS1 (0.51) KDM4EALDH1A1RAB9ANPC1HDAC3
SCHEMBL435263 0.77 ALDH1A1 (0.49) KDM4EALDH1A1L3MBTL1RAB9ANPC1
SCHEMBL14232845 0.77 NPC1 (0.41) KDM4EALDH1A1L3MBTL1RAB9ANPC1
SCHEMBL6394324 0.76 RAB9A (0.64) KDM4EALDH1A1RAB9ANPC1HDAC3
SCHEMBL820774 0.76 RAB9A (0.60) KDM4EALDH1A1RAB9ANPC1HDAC3
SCHEMBL25541163 0.76 ALDH1A1 (0.55) KDM4EALDH1A1L3MBTL1HPGDHTT
SCHEMBL7316037 0.75 KDM4E (0.56) KDM4EALDH1A1L3MBTL1HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326790-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2025-10-23 — — US claimed
EP-4298110-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2024-01-03 — — EP claimed
WO-2022180410-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2022-09-01 — — WO claimed
US-20250326790-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2025-10-23 — — US disclosed
EP-4298110-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2024-01-03 — — EP disclosed
WO-2022180410-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE UNIVERSITY OF SOUTHAMPTON (GB) 2022-09-01 — — WO disclosed
US-20160318856-A1 Substituted Urea eIF2alpha Kinase Activators NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-11-03 — — US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 — — US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
WO-2012162025-A1 METHODS OF SELECTING CANCER PATIENTS FOR TREATMENT WITH N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-11-29 — — WO disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed
WO-2010138820-A2 N,N-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-12-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation NSUN2, EIF2AK2, RNGTT KDM4E 1117/4885ALDH1A1 3464/4885L3MBTL1 462/4885
US-20160318856-A1 Substituted Urea eIF2alpha Kinase Activators EIF2AK1, EIF2A, EIF4A2 KDM4E 872/4885ALDH1A1 4322/4885L3MBTL1 881/4885
US-20250326790-A1 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE HIF1A, HIF1AN, HYOU1 KDM4E 3268/4885ALDH1A1 3674/4885L3MBTL1 1115/4885
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION NSUN2, EIF2AK2, RNGTT KDM4E 1117/4885ALDH1A1 3464/4885L3MBTL1 462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.