SCHEMBL4550458

SCHEMBL4550458

NCc1ccnc(OCC(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 16/20 0.59
LOX P28300 9/20 0.59
LOXL3 P58215 1/20 0.46
EPHX2 P34913 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
THRB P10828 1/20 0.38
G6PD P11413 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30398543 1.00 LOXL2 (0.59) LOXL2LOXLOXL3EPHX2ALDH1A1
Hydrochloric Acid SCHEMBL22287295 0.98 LOXL2 (0.60) LOXL2LOXLOXL3EPHX2
Hydrochloric Acid SCHEMBL4770701 0.98 LOXL2 (0.57) LOXL2LOXLOXL3EPHX2ALDH1A1
Hydrochloric Acid SCHEMBL4770707 0.98 LOXL2 (0.60) LOXL2LOXLOXL3EPHX2
SCHEMBL30931697 0.87 LOXL2 (0.56) LOXL2LOXLOXL3
SCHEMBL30931725 0.87 LOXL2 (0.60) LOXL2LOXLOXL3
Hydrochloric Acid SCHEMBL25200556 0.85 LOXL2 (0.58) LOXL2LOXLOXL3
SCHEMBL4343502 0.83 LOXL2 (0.56) LOXL2LOXLOXL3
SCHEMBL15670435 0.83 RECQL (0.46) LOXL2LOXEPHX2ALDH1A1MAPT
SCHEMBL18083226 0.83 NOS3 (0.46) LOXL2LOXEPHX2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4630404-A1 UREA COMPOUNDS AS ACTIVATORS OF POTASSIUM CHANNELS KV7.2/7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS ANGELINI PHARMA S.P.A. (IT) 2025-10-15 EP disclosed
EP-4630406-A1 AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS ANGELINI PHARMA S.P.A. (IT) 2025-10-15 EP disclosed
US-20250282725-A1 KCNQ POTENTIATORS Eii Lilly and Company 2025-09-11 US disclosed
US-12344584-B2 KCNQ potentiators ELI LILLY AND COMPANY (US) 2025-07-01 US disclosed
US-20250074901-A1 NOVEL HETEROARYL COMPOUNDS ANGELINI PHARMA S.P.A. (IT) 2025-03-06 US disclosed
EP-4452944-A1 CYCLOPROPYL COMPOUNDS Icagen, LLC (US) 2024-10-30 EP disclosed
US-20240336571-A1 NOVEL CYCLOPROPYL COMPOUNDS ANGELINI PHARMA S.P.A. (IT) 2024-10-10 US disclosed
EP-4433453-A1 NOVEL HETEROARYL-UREA COMPOUNDS AS KV7.2 INHIBITORS Icagen, LLC (US) 2024-09-25 EP disclosed
WO-2024121046-A1 AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS ANGELINI PHARMA S.P.A. (IT) 2024-06-13 WO disclosed
WO-2024121048-A1 UREA COMPOUNDS AS ACTIVATORS OF POTASSIUM CHANNELS KV7.2/7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS ANGELINI PHARMA S.P.A. (IT) 2024-06-13 WO disclosed
CN-113692304-A 1- ((2- (2,2, 2-trifluoroethoxy) pyridin-4-yl) methyl) urea derivatives as KCNQ enhancers 礼来公司 2021-11-23 CN disclosed
WO-2020163268-A1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS ELI LILLY AND COMPANY (US) 2020-08-13 WO disclosed
WO-2020163268-A1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS ELI LILLY AND COMPANY (US) 2020-08-13 WO disclosed
US-20200247752-A1 KCNQ Potentiators ELI LILLY AND COMPANY (US) 2020-08-06 US disclosed
US-20200247752-A1 KCNQ Potentiators ELI LILLY AND COMPANY (US) 2020-08-06 US disclosed
US-9302991-B2 Arylamide derivatives as TTX-S blockers RAQUALIA PHARMA INC. (JP) 2016-04-05 US disclosed
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2014-11-13 US disclosed
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2014-11-13 US disclosed
WO-2012152983-A1 PHENYL- SULFONYL DERIVATIVES AS MEDIATORS OF TRPA1 RECEPTOR ACTIVITY FOR THE TREATMENT OF PAIN ORION CORPORATION (FI) 2012-11-15 WO disclosed
WO-2012053186-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2012-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282725-A1 KCNQ POTENTIATORS KCNN3, KCNQ1, KCNN1 LOXL2 2699/4885LOX 2272/4885LOXL3 2628/4885
US-20250074901-A1 NOVEL HETEROARYL COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP3A43, F12 LOXL2 3167/4885LOX 3544/4885LOXL3 1161/4885
US-20200247752-A1 KCNQ Potentiators KCNN3, KCNQ1, KCNN1 LOXL2 2699/4885LOX 2272/4885LOXL3 2628/4885
US-12344584-B2 KCNQ potentiators KCNN3, KCNQ1, KCNN1 LOXL2 2699/4885LOX 2272/4885LOXL3 2628/4885
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS SCN2B, SCN1B, SCN2A LOXL2 2082/4885LOX 2625/4885LOXL3 2030/4885
US-20240336571-A1 NOVEL CYCLOPROPYL COMPOUNDS C1R, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CNR1 LOXL2 4525/4885LOX 4419/4885LOXL3 3535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.