Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19009218 | 0.80 | MAPK14 (0.50) | MAPK14ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL4552886 | 0.75 | FEN1 (0.51) | ADORA2AADORA1MAPK8ADORA2BMAPT | |
| SCHEMBL4621924 | 0.73 | ALDH1A1 (0.59) | MAPK8PGRALDH1A1KDM4ELMNA | |
| SCHEMBL2068569 | 0.73 | FEN1 (0.46) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL13866623 | 0.72 | PTGER4 (0.59) | MAPK14ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL17434075 | 0.72 | ALDH1A1 (0.49) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL17434239 | 0.72 | ALDH1A1 (0.41) | ADORA2AADORA1MAPK8PGRADORA2B | |
| SCHEMBL6362477 | 0.72 | PGR (0.68) | MAPK8PGRALDH1A1KDM4EMAPK1 | |
| SCHEMBL30485670 | 0.72 | PGR (0.68) | MAPK8PGRALDH1A1KDM4EMAPK1 | |
| SCHEMBL1666075 | 0.71 | NR3C1 (0.44) | MAPK14KDM4ELMNAMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | CMA1, SERPINB1, CTSC | CMA1 1/4885ADORA2A 4651/4885ADORA3 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.