Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28011943 | 0.89 | MEN1 (0.45) | — | |
| SCHEMBL10698086 | 0.82 | MCL1 (0.56) | DHODHMCL1PTGER1BAK1PTPN1 | |
| SCHEMBL9191607 | 0.76 | DHODH (0.49) | DHODHMCL1PTGER1BAK1PTPN1 | |
| SCHEMBL27678664 | 0.76 | PTGER1 (0.51) | MCL1PTGER1BAK1PTPN1 | |
| SCHEMBL7916872 | 0.74 | MAOB (0.52) | MCL1PTGER1BAK1PTPN1 | |
| SCHEMBL4551574 | 0.74 | PRMT5 (0.49) | DHODHMCL1POLBPTPN1 | |
| SCHEMBL12379065 | 0.72 | PTGER1 (0.53) | MCL1PTGER1BAK1PTPN1 | |
| SCHEMBL8896984 | 0.71 | PTGER1 (0.51) | MCL1PTGER1 | |
| SCHEMBL1396290 | 0.71 | ALDH1A1 (0.57) | MCL1PTGER1PTPN1 | |
| SCHEMBL4132651 | 0.71 | MCL1 (0.61) | DHODHMCL1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |