SCHEMBL455298

SCHEMBL455298

CCc1cc(-c2ccccc2)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.47
ERCC5 P28715 1/20 0.46
FEN1 P39748 1/20 0.46
DCLRE1A Q6PJP8 1/20 0.43
DCLRE1B Q9H816 1/20 0.43
CYP1A2 P05177 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
BCL2 P10415 1/20 0.42
HIF1A Q16665 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.40
HSD17B1 P14061 2/20 0.40
AHR P35869 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
F11 P03951 1/20 0.39
SUCNR1 Q9BXA5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL458111 0.84 ESR2 (0.52) ESR2ERCC5FEN1DCLRE1ADCLRE1B
SCHEMBL27739733 0.82 ESR2 (0.48) ESR2ERCC5FEN1DCLRE1ADCLRE1B
SCHEMBL30380433 0.81 DCLRE1A (0.47) DCLRE1ADCLRE1BCYP1A2SMN1; SMN2BCL2
SCHEMBL28992451 0.81 DCLRE1A (0.47) DCLRE1ADCLRE1BCYP1A2SMN1; SMN2BCL2
SCHEMBL6772798 0.80 ESR2 (0.47) ESR2ERCC5FEN1DCLRE1ADCLRE1B
SCHEMBL27489870 0.79 ERCC5 (0.43) ESR2ERCC5FEN1DCLRE1ADCLRE1B
SCHEMBL9618333 0.78 SMN1; SMN2 (0.47) DCLRE1ADCLRE1BCYP1A2SMN1; SMN2BCL2
SCHEMBL27141469 0.77 ACLY (0.56) ERCC5FEN1DCLRE1ADCLRE1BCYP1A2
SCHEMBL1023129 0.76 HSD17B1 (0.66) ESR2DCLRE1ADCLRE1BCYP1A2BCL2
SCHEMBL8369434 0.76 IKBKB (0.50) DCLRE1ADCLRE1BCYP1A2SMN1; SMN2BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021261461-A1 COMPOUNDS, MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES, ORGANIC ELECTROLUMINESCENT DEVICES, AND ELECTRONIC DEVICES 出光興産株式会社 2021-12-30 WO disclosed
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed