Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476215 | 0.78 | ALDH1A1 (0.58) | GPR119ALDH1A1MAPTL3MBTL1KMT2A | |
| SCHEMBL7167709 | 0.77 | CYP1A2 (0.42) | GPR119ALDH1A1MAPTLMNAGBA1 | |
| SCHEMBL15028316 | 0.76 | PDE4B (0.49) | GPR119ALDH1A1 | |
| SCHEMBL13156608 | 0.76 | SMARCA2 (0.48) | GPR119ALDH1A1MAPTLMNAGBA1 | |
| SCHEMBL25003642 | 0.75 | HTR1A (0.48) | GPR119ALDH1A1MAPTLMNAGBA1 | |
| SCHEMBL17996847 | 0.75 | DTYMK (0.48) | GPR119ALDH1A1MAPTLMNAGBA1 | |
| SCHEMBL5248562 | 0.75 | GPR119 (0.46) | GPR119ALDH1A1MEN1KMT2A | |
| SCHEMBL2274835 | 0.75 | GBA1 (0.55) | GPR119ALDH1A1MAPTLMNAGBA1 | |
| SCHEMBL110679 | 0.75 | GPR119 (0.54) | GPR119ALDH1A1MAPTLMNACKS1B | |
| SCHEMBL5573222 | 0.75 | MAPT (0.76) | GPR119ALDH1A1MAPTLMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |