Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17018582 | 0.74 | CYP2C19 (0.44) | GPR119RXFP1POLBLMNAMEN1 | |
| SCHEMBL4597509 | 0.73 | LMNA (0.40) | RXFP1POLBLMNANPSR1MEN1 | |
| SCHEMBL1558558 | 0.72 | KCNA3 (0.39) | GPR119KDM1AMAOBMEN1KMT2A | |
| SCHEMBL4437715 | 0.71 | GPR119 (0.36) | GPR119CCKBRLMNANPSR1MEN1 | |
| SCHEMBL1557162 | 0.68 | NFKB1 (0.40) | KDM1AMAOBKMT2ANFKB1NFKB2 | |
| SCHEMBL3726743 | 0.64 | GAA (0.42) | RXFP1POLBLMNAMEN1KMT2A | |
| SCHEMBL5394420 | 0.64 | KDM1A (0.42) | GPR119KDM1AMAOBMEN1KMT2A | |
| SCHEMBL17330297 | 0.63 | CHRM3 (0.42) | KMT2AMAPT | |
| SCHEMBL8966117 | 0.63 | HSD17B10 (0.59) | RXFP1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL29991501 | 0.63 | HSD17B10 (0.59) | RXFP1NPSR1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124913-A1 | 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS | Novartis AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077597-A1 | 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |