Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965856 | 0.87 | HTT (0.40) | CA12CA9BRD4BRPF1KAT2B | |
| SCHEMBL4554436 | 0.84 | MAPT (0.42) | CDC7CDK2MAPTRAPGEF4 | |
| SCHEMBL4553594 | 0.83 | KDM4E (0.35) | ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4553471 | 0.83 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1CDK2KDM4E | |
| SCHEMBL4554908 | 0.83 | CDC7 (0.37) | CDC7CDK2ROCK1MAPT | |
| SCHEMBL962637 | 0.83 | ALDH1A1 (0.50) | CA12CA9BRD4BRPF1KAT2B | |
| SCHEMBL962635 | 0.83 | ALDH1A1 (0.50) | CA12CA9BRD4BRPF1KAT2B | |
| SCHEMBL4554658 | 0.83 | CYP1A2 (0.31) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL4565958 | 0.82 | ROCK1 (0.41) | ALDH1A1SMN1; SMN2L3MBTL1ROCK1KDM4E | |
| SCHEMBL4554187 | 0.82 | HTR2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |