Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554908 | 0.91 | CDC7 (0.37) | HTR2AHTR2CMAPT | |
| SCHEMBL962714 | 0.88 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL4554187 | 0.87 | HTR2A (0.33) | HTR2AHTR2C | |
| SCHEMBL4553471 | 0.86 | SMN1; SMN2 (0.38) | KDM4EALDH1A1HPGDHTR2AHTR2C | |
| SCHEMBL4565958 | 0.85 | ROCK1 (0.41) | KDM4EALDH1A1HPGDHSD17B10HTR2C | |
| SCHEMBL962979 | 0.84 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL966011 | 0.84 | KDM4E (0.34) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL966013 | 0.84 | KDM4E (0.34) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL962977 | 0.84 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL4554759 | 0.84 | SMN1; SMN2 (0.38) | KDM4EALDH1A1HPGDHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |