Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553105 | 0.92 | ROCK1 (0.41) | ROCK1PDGFRBPDGFRASMN1; SMN2POLB | |
| SCHEMBL4554315 | 0.90 | ROCK1 (0.41) | ROCK1PDGFRBPDGFRASMN1; SMN2POLB | |
| SCHEMBL967587 | 0.90 | ROCK1 (0.44) | ROCK1PDGFRBPDGFRASMN1; SMN2L3MBTL1 | |
| SCHEMBL4553594 | 0.85 | KDM4E (0.35) | KDM4EALDH1A1HPGDHSD17B10HTR2C | |
| SCHEMBL4553471 | 0.85 | SMN1; SMN2 (0.38) | PDGFRBSMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL961757 | 0.85 | ALDH1A1 (0.45) | ROCK1PDGFRBPDGFRASMN1; SMN2L3MBTL1 | |
| SCHEMBL961756 | 0.85 | ALDH1A1 (0.45) | ROCK1PDGFRBPDGFRASMN1; SMN2L3MBTL1 | |
| SCHEMBL4554759 | 0.83 | SMN1; SMN2 (0.38) | PDGFRBSMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4553928 | 0.82 | CA12 (0.35) | ROCK1SMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4554187 | 0.82 | HTR2A (0.33) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |