Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553594 | 0.91 | KDM4E (0.35) | HTR2CHTR2AMAPT | |
| SCHEMBL966593 | 0.88 | CDC7 (0.40) | CDC7CDK2ROCK1HTR2CHTR2A | |
| SCHEMBL4554187 | 0.87 | HTR2A (0.33) | HTR2CHTR2A | |
| SCHEMBL4553105 | 0.84 | ROCK1 (0.41) | ROCK1HTR2CHTR2AMAPT | |
| SCHEMBL963737 | 0.84 | ALDH1A1 (0.46) | CDC7CDK2ROCK1MAPTMET | |
| SCHEMBL963735 | 0.84 | ALDH1A1 (0.46) | CDC7CDK2ROCK1MAPTMET | |
| SCHEMBL4553928 | 0.83 | CA12 (0.35) | CDC7CDK2ROCK1MAPT | |
| SCHEMBL4554315 | 0.82 | ROCK1 (0.41) | ROCK1HTR2CHTR2AMAPT | |
| SCHEMBL4554436 | 0.81 | MAPT (0.42) | CDC7CDK2MAPT | |
| SCHEMBL4553471 | 0.80 | SMN1; SMN2 (0.38) | CDK2HTR2CHTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |