Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553763 | 0.95 | ADA (0.31) | KMONPY5R | |
| SCHEMBL4554742 | 0.89 | MAPK8 (0.31) | NPY5RMAPK8MAPK9MAPK10 | |
| SCHEMBL4554506 | 0.88 | NPY5R (0.38) | KMONPY5R | |
| SCHEMBL4555123 | 0.86 | MAPK8 (0.33) | NPY5RCDK2MAPK8MAPK9MAPK10 | |
| SCHEMBL4554830 | 0.83 | OXER1 (0.31) | — | |
| SCHEMBL4553884 | 0.82 | IRAK4 (0.33) | NPY5R | |
| SCHEMBL4554437 | 0.82 | MAPK8 (0.32) | KMOCDC7CDK2ROCK1MAP3K14 | |
| SCHEMBL4554653 | 0.81 | NPY5R (0.38) | NPY5R | |
| SCHEMBL4553446 | 0.81 | MEN1 (0.40) | — | |
| SCHEMBL4553761 | 0.79 | MAPK8 (0.31) | KMOMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |