Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 9/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555123 | 0.89 | MAPK8 (0.33) | MEN1KMT2APHGDHROCK2PIM1 | |
| SCHEMBL4554742 | 0.86 | MAPK8 (0.31) | PHGDHROCK2PIM1PIM3TRPM8 | |
| SCHEMBL4553884 | 0.86 | IRAK4 (0.33) | PHGDHROCK2PIM1PIM3 | |
| SCHEMBL4554653 | 0.86 | NPY5R (0.38) | PHGDHROCK2PIM1PIM3 | |
| SCHEMBL4554830 | 0.84 | OXER1 (0.31) | PHGDH | |
| SCHEMBL4553442 | 0.83 | MEN1 (0.41) | MEN1KMT2APHGDHHDAC8ROCK2 | |
| SCHEMBL4554440 | 0.81 | KMO (0.31) | — | |
| SCHEMBL4553763 | 0.80 | ADA (0.31) | — | |
| SCHEMBL4554506 | 0.79 | NPY5R (0.38) | — | |
| SCHEMBL4555121 | 0.76 | MAPK8 (0.35) | MEN1KMT2APHGDHROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |