Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10616097 | 0.83 | ENPP2 (0.47) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL6557274 | 0.76 | ENPP2 (0.42) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL8634688 | 0.75 | FAAH (0.48) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL10917863 | 0.75 | FAAH (0.54) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL2251339 | 0.75 | ENPP2 (0.44) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL3217870 | 0.74 | ENPP2 (0.41) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL28391254 | 0.74 | ENPP2 (0.41) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL11881585 | 0.73 | AKR1B1 (0.50) | FAAHCES1CES2TSHR | |
| Hydrochloric Acid SCHEMBL4601129 | 0.73 | ENPP2 (0.40) | ENPP2FAAHCA2CES1CES2 | |
| SCHEMBL30554612 | 0.73 | ENPP2 (0.44) | ENPP2FAAHCA2CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049120-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008016534-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | WO | claimed |
| EP-2049120-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008016534-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | WO | disclosed |