Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 11/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554899 | 0.83 | MTNR1B (0.38) | MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL4555618 | 0.82 | MTNR1B (0.42) | MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL4554533 | 0.81 | DPP4 (0.35) | KMT2APOLB | |
| SCHEMBL3664253 | 0.78 | MTNR1B (0.47) | MTNR1BMTNR1AHHAT | |
| SCHEMBL3665398 | 0.77 | ROCK2 (0.44) | MTNR1BMTNR1A | |
| SCHEMBL4032581 | 0.76 | MTNR1B (0.48) | MTNR1BMTNR1A | |
| SCHEMBL2123940 | 0.75 | MTNR1B (0.47) | MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL4555438 | 0.73 | MTNR1B (0.38) | MTNR1BMTNR1A | |
| SCHEMBL2123210 | 0.73 | MTNR1B (0.45) | MTNR1BMTNR1A | |
| SCHEMBL2123219 | 0.72 | MTNR1B (0.43) | MTNR1BMTNR1AHHAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125799-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008104524-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-04 | — | — | WO | disclosed |