Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 5/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553186 | 0.87 | FFAR1 (0.44) | FFAR1 | |
| SCHEMBL4554892 | 0.85 | FFAR1 (0.43) | MTNR1BFFAR1MTNR1A | |
| SCHEMBL4555437 | 0.84 | FFAR1 (0.38) | FFAR1 | |
| SCHEMBL4555618 | 0.80 | MTNR1B (0.42) | MTNR1BMTNR1A | |
| SCHEMBL3665398 | 0.78 | ROCK2 (0.44) | MTNR1BMTNR1A | |
| SCHEMBL13347339 | 0.76 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL4554534 | 0.73 | MTNR1B (0.40) | MTNR1BMTNR1A | |
| SCHEMBL2123940 | 0.73 | MTNR1B (0.47) | MTNR1BMTNR1A | |
| SCHEMBL4553185 | 0.72 | FFAR1 (0.45) | FFAR1 | |
| SCHEMBL14063017 | 0.72 | FFAR1 (0.41) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125799-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008104524-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-04 | — | — | WO | disclosed |