Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2288155 | 0.88 | EPHX2 (0.51) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL2288180 | 0.74 | NR1H4 (0.56) | MLYCDCYP4Z1MAPK14 | |
| SCHEMBL3163495 | 0.70 | SCN3A (0.68) | LMNA | |
| SCHEMBL4404243 | 0.70 | LMNA (0.54) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL17864341 | 0.69 | LMNA (0.60) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL4239181 | 0.69 | LMNA (0.58) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL4239185 | 0.69 | LMNA (0.58) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL13701947 | 0.68 | L3MBTL1 (0.62) | KLKB1KLK1LMNAROCK2ROCK1 | |
| SCHEMBL12643749 | 0.68 | PPID (0.59) | KLKB1KLK1LMNAPI4KBKDM4E | |
| SCHEMBL2287160 | 0.68 | EPHX2 (0.54) | KLKB1KLK1ROCK2ROCK1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119476-B1 | Amide derivatives as positive allosteric modulators and methods of use thereof | ABBVIE INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2119476-A2 | Amide derivatives as positive allosteric modulators and methods of use thereof | ABBOTT LABORATORIES (US) | 2009-11-18 | — | — | EP | disclosed |