Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554658 | 0.88 | CYP1A2 (0.31) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL967577 | 0.88 | CYP1A2 (0.42) | NOTUMCYP1A2CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL964286 | 0.84 | L3MBTL1 (0.50) | NOTUMCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL964287 | 0.84 | L3MBTL1 (0.50) | NOTUMCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL4553928 | 0.81 | CA12 (0.35) | NOTUMCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL4553471 | 0.77 | SMN1; SMN2 (0.38) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL963202 | 0.76 | CYP1A2 (0.38) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL4554759 | 0.75 | SMN1; SMN2 (0.38) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL967508 | 0.74 | PPARG (0.43) | — | |
| SCHEMBL967509 | 0.74 | PPARG (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |