Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30476362 | 0.78 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL20818548 | 0.78 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL27808748 | 0.78 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL4552449 | 0.76 | RAB9A (0.40) | ALDH1A1RAB9A | |
| SCHEMBL7956403 | 0.73 | GPR119 (0.54) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL3782855 | 0.73 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL14040808 | 0.72 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL21876063 | 0.72 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL4123229 | 0.71 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 | |
| SCHEMBL70137 | 0.71 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1NPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008111010-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2008-09-18 | — | — | WO | disclosed |