Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554838 | 0.81 | CHRM1 (0.40) | WDR5CHRM1BRD4ADRA2AADRA2C | |
| SCHEMBL6420682 | 0.77 | DRD2 (0.50) | MAPTHTR1ADRD2HTR6DRD4 | |
| SCHEMBL8514471 | 0.75 | S1PR1 (0.42) | MAPTALDH1A1HTR1ADRD2DRD4 | |
| SCHEMBL4554365 | 0.75 | KDM4E (0.44) | POLBALDH1A1DRD2HTR6DRD3 | |
| SCHEMBL5915129 | 0.75 | HTR1A (0.54) | BRD4ALDH1A1HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL18037806 | 0.74 | KDM4E (0.46) | MAPTPOLBALDH1A1KMT2A | |
| SCHEMBL18766585 | 0.71 | PTPN1 (0.39) | CHRM1PTPN1MAPTPOLBALDH1A1 | |
| SCHEMBL10309775 | 0.70 | GAA (0.45) | MAPTALDH1A1KMT2A | |
| SCHEMBL1355391 | 0.69 | ALDH1A1 (0.52) | MAPTALDH1A1 | |
| Phthalic Acid SCHEMBL4952404 | 0.68 | ALDH1A1 (0.54) | POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |