Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554837 | 0.81 | WDR5 (0.41) | CHRM1BRD4ALDH1A1WDR5ADRA2A | |
| SCHEMBL4554366 | 0.74 | KDM2B (0.43) | ALDH1A1KMT2A | |
| SCHEMBL5915128 | 0.74 | HTR2C (0.51) | BRD4ALDH1A1CLCN2HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL18037807 | 0.73 | KMO (0.44) | ALDH1A1CLCN2KMT2A | |
| SCHEMBL18766586 | 0.69 | ALDH1A1 (0.41) | BRD4ALDH1A1CLCN2SLC6A1DRD2 | |
| SCHEMBL18766587 | 0.69 | ALDH1A1 (0.41) | BRD4ALDH1A1CLCN2SLC6A1DRD2 | |
| SCHEMBL31212938 | 0.68 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CESR1ESR2 | |
| SCHEMBL16874956 | 0.68 | MYC (0.49) | ALDH1A1WDR5ADRA2AADRA2BADRA2C | |
| SCHEMBL15548445 | 0.68 | MYC (0.49) | ALDH1A1WDR5ADRA2AADRA2BADRA2C | |
| SCHEMBL18983054 | 0.67 | CLCN2 (0.56) | ALDH1A1CLCN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |