Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCTP | Q9UKL6 | 7/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | STARD10 | Q9Y365 | 3/20 | 0.72 |
| ▸ | STARD7 | Q9NQZ5 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | FASN | P49327 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29083660 | 0.91 | PCTP (0.71) | PCTPLMNASTARD10STARD7KDM4E | |
| SCHEMBL1234613 | 0.90 | PCTP (1.00) | PCTPLMNASTARD10STARD7KDM4E | |
| SCHEMBL13470343 | 0.84 | PCTP (0.85) | PCTPLMNASTARD10STARD7KDM4E | |
| SCHEMBL1233504 | 0.84 | PCTP (1.00) | PCTPLMNASTARD10STARD7KMT2A | |
| SCHEMBL29776905 | 0.83 | TSHR (0.73) | LMNAKMT2AGAA | |
| SCHEMBL13453716 | 0.83 | PCTP (0.80) | PCTPSTARD10STARD7KDM4EMAPT | |
| SCHEMBL16358817 | 0.82 | LMNA (0.71) | LMNAKMT2AMEN1GAA | |
| SCHEMBL4548140 | 0.81 | LMNA (0.69) | PCTPLMNAMAPTKMT2AMEN1 | |
| SCHEMBL1233511 | 0.81 | PCTP (1.00) | PCTPLMNASTARD10STARD7GAA | |
| SCHEMBL1233510 | 0.81 | PCTP (1.00) | PCTPLMNASTARD10STARD7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | PCTP 2258/4885LMNA 448/4885STARD10 2439/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | PCTP 2258/4885LMNA 448/4885STARD10 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.