Sugi Predict

Sugi Predict / Compounds / SCHEMBL4548140

SCHEMBL4548140

SCHEMBL4548140

Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)n1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.69
▸ GAA P10253 1/20 0.63
▸ FASN P49327 1/20 0.59
▸ ALDH1A1 P00352 2/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ GLA P06280 1/20 0.58
▸ TP53 P04637 1/20 0.57
▸ MAPT P10636 1/20 0.57
▸ EPHX2 P34913 1/20 0.57
▸ PCTP Q9UKL6 1/20 0.56
▸ MEN1 O00255 1/20 0.55
▸ IDH1 O75874 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ HDAC3 O15379 2/20 0.54
▸ HDAC4 P56524 2/20 0.54
▸ HDAC1 Q13547 2/20 0.54
▸ HDAC7 Q8WUI4 2/20 0.54
▸ HDAC2 Q92769 2/20 0.54
▸ HDAC10 Q969S8 2/20 0.54
▸ HDAC11 Q96DB2 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7081820 0.84 ADRA2B (0.56) LMNAGAAALDH1A1KMT2AGLA
SCHEMBL4554977 0.81 PCTP (0.80) LMNAGAAFASNKMT2AMAPT
SCHEMBL6843412 0.80 PTGDR2 (0.52) GAAALDH1A1KMT2ATP53MEN1
SCHEMBL12010878 0.80 IDH1 (0.70) LMNAGAAKMT2ATP53MAPT
SCHEMBL19900254 0.79 EPHX2 (0.59) GAAKMT2ATP53MAPTEPHX2
SCHEMBL18038048 0.79 EPHX2 (0.59) GAAKMT2AMAPTEPHX2MEN1
SCHEMBL19900458 0.78 EPHX2 (0.58) GAAKMT2ATP53MAPTEPHX2
SCHEMBL19900427 0.78 EPHX2 (0.58) GAAKMT2ATP53MAPTEPHX2
SCHEMBL23258359 0.78 EPHX2 (0.54) LMNAGAAKMT2AMAPTEPHX2
SCHEMBL13429325 0.78 EPHX2 (0.73) ALDH1A1KMT2ATP53MAPTEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9932300-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2018-04-03 — — US disclosed
US-9932300-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2018-04-03 — — US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 — — US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation NSUN2, EIF2AK2, RNGTT LMNA 448/4885GAA 2514/4885FASN 1309/4885
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION NSUN2, EIF2AK2, RNGTT LMNA 448/4885GAA 2514/4885FASN 1309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.