Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963547 | 0.89 | SMN1; SMN2 (0.41) | MEN1LMNAPABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL963160 | 0.85 | HTT (0.32) | MEN1LMNAPABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL967192 | 0.85 | L3MBTL1 (0.48) | MEN1LMNAPABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL967190 | 0.85 | L3MBTL1 (0.48) | MEN1LMNAPABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL963163 | 0.85 | HTT (0.32) | MEN1LMNAPABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL4553471 | 0.82 | SMN1; SMN2 (0.38) | MEN1KMT2ASMN1; SMN2HTTHPGD | |
| SCHEMBL967738 | 0.81 | ALDH1A1 (0.41) | LMNASMN1; SMN2HTTHPGDHSD17B10 | |
| SCHEMBL4554491 | 0.81 | L3MBTL1 (0.38) | SMN1; SMN2CYP2C19 | |
| SCHEMBL4554759 | 0.80 | SMN1; SMN2 (0.38) | MEN1KMT2ASMN1; SMN2HTTHPGD | |
| SCHEMBL967739 | 0.78 | IRAK4 (0.35) | LMNASMN1; SMN2HTTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |