Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL962123 | 0.88 | L3MBTL1 (0.40) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL965190 | 0.84 | ALDH1A1 (0.47) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL964355 | 0.84 | L3MBTL1 (0.39) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL964353 | 0.84 | L3MBTL1 (0.39) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL965188 | 0.84 | ALDH1A1 (0.47) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL4553928 | 0.82 | CA12 (0.35) | L3MBTL1CDC7CDK2RAPGEF4CYP2C19 | |
| SCHEMBL4555113 | 0.81 | MEN1 (0.35) | CYP2C19SMN1; SMN2 | |
| SCHEMBL962300 | 0.80 | LMNA (0.38) | L3MBTL1SLC22A12PARP1MTNR1AENPP3 | |
| SCHEMBL967688 | 0.79 | PARP1 (0.40) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 | |
| SCHEMBL967690 | 0.79 | PARP1 (0.40) | L3MBTL1CDC7CDK2RAPGEF4SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |