Sugi Predict

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SCHEMBL4555170

SCHEMBL4555170

CC(C)(C)OC(=O)N1C(=O)CC[C@H]1C(O[SiH2]C(C)(C)C)(c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 1/20 0.37
▸ WNT3 P56703 1/20 0.35
▸ SFRP1 Q8N474 1/20 0.35
▸ KLK7 P49862 2/20 0.35
▸ KLK5 Q9Y337 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ MEN1 O00255 3/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ RORC P51449 2/20 0.34
▸ LMNA P02545 1/20 0.33
▸ BRD9 Q9H8M2 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ JAK1 P23458 1/20 0.33
▸ USP30 Q70CQ3 1/20 0.33
▸ STS P08842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL211420 0.81 CHRM2 (0.36) GPR119WNT3SFRP1KDM4E
SCHEMBL6481828 0.79 KLK7 (0.37) GPR119KLK7KLK5KDM4EPKM
SCHEMBL15519210 0.77 RIPK1 (0.38) GPR119KLK7KLK5KDM4EPKM
SCHEMBL9929890 0.76 USP30 (0.43) GPR119WNT3SFRP1KLK7KLK5
SCHEMBL9929891 0.76 USP30 (0.43) GPR119WNT3SFRP1KLK7KLK5
SCHEMBL29582579 0.76 USP30 (0.43) GPR119WNT3SFRP1KLK7KLK5
SCHEMBL11917918 0.73 CHRM2 (0.42) GPR119KDM4E
SCHEMBL7589379 0.72 L3MBTL1 (0.51) GPR119MEN1KMT2ARORC
SCHEMBL31133635 0.71 CHRM2 (0.41) GPR119WNT3SFRP1KDM4ESTS
SCHEMBL17113461 0.71 CHRM2 (0.41) GPR119WNT3SFRP1KDM4ESTS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2094711-B1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THE PHARMACEUTICAL USE THEREOF FORSCHUNGSVERBUND BERLIN EV (DE) 2014-03-19 — — EP disclosed
EP-2094711-A1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THE PHARMACEUTICAL USE THEREOF Forschungsverbund Berlin e.V. (DE) 2009-09-02 — — EP disclosed
WO-2008040332-A1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THE PHARMACEUTICAL USE THEREOF FORSCHUNGSVERBUND BERLIN E.V. (DE) 2008-04-10 — — WO disclosed
US-7037911-B2 Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2006-05-02 — — US disclosed
EP-1523483-A4 AMINO-BICYCLIC PYRAZINONES AND PYRIDINONES AS COAGULATION SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2006-03-08 — — EP disclosed
EP-1523483-A2 AMINO-BICYCLIC PYRAZINONES AND PYRIDINONES AS COAGULATION SERINE PROTEASE INHIBITORS Bristol-Myers Squibb Company (US) 2005-04-20 — — EP disclosed
US-20050038030-A1 Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors BRISTOL-MYERS SQUIBB COMPANY 2005-02-17 — — US disclosed
WO-2004002405-A2 AMINO-BICYCLIC PYRAZINONES AND PYRIDINONES BRISTOL-MYERS SQUIBB COMPANY (US) 2004-01-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038030-A1 Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors TFPI, F5, F2 GPR119 4571/4885WNT3 3701/4885SFRP1 644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.