Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555291 | 1.00 | ADH1C (0.33) | ADH1CADH1AADH4SPHK1HSD11B1 | |
| SCHEMBL509386 | 0.85 | CCR5 (0.37) | HSD11B1 | |
| SCHEMBL509385 | 0.85 | CCR5 (0.37) | HSD11B1 | |
| SCHEMBL509697 | 0.84 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL509698 | 0.84 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL508875 | 0.79 | CCR5 (0.32) | HSD11B1 | |
| SCHEMBL508874 | 0.79 | CCR5 (0.32) | HSD11B1 | |
| SCHEMBL14204669 | 0.77 | L3MBTL1 (0.39) | HSD11B1 | |
| SCHEMBL510107 | 0.76 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL510106 | 0.76 | HSD11B1 (0.44) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137143-A1 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES | Nabriva Therapeutics AG (AT) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008113089-A1 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES | NABRIVA THERAPEUTICS AG (AT) | 2008-09-25 | — | — | WO | disclosed |