Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28812647 | 0.84 | FABP4 (0.57) | FABP4SCN9ABCAT2PARP1NR1H2 | |
| SCHEMBL530568 | 0.83 | FABP4 (0.58) | FABP4SCN9ABCAT2PARP1NR1H2 | |
| SCHEMBL30339795 | 0.83 | FABP4 (0.58) | FABP4SCN9ABCAT2PARP1NR1H2 | |
| SCHEMBL29286691 | 0.77 | PARP1 (0.40) | FABP4SCN9APARP1PDK2CYP3A4 | |
| SCHEMBL6173681 | 0.76 | PARP1 (0.52) | SCN9ABCAT2PARP1PDK2TAS2R14 | |
| SCHEMBL30241242 | 0.76 | FABP4 (0.45) | FABP4SCN9APARP1NR1H2NR1H3 | |
| SCHEMBL4555403 | 0.75 | BRD4 (0.41) | FABP4SCN9APARP1PDK2MYC | |
| SCHEMBL4776531 | 0.74 | FABP4 (0.46) | FABP4SCN9ABCAT2PARP1NR1H2 | |
| SCHEMBL7161543 | 0.74 | BCAT2 (0.51) | FABP4SCN9ABCAT2PARP1NR1H2 | |
| SCHEMBL27475690 | 0.74 | BCAT2 (0.47) | FABP4BCAT2MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |