Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.51 |
| ▸ | PRKDC | P78527 | 2/20 | 0.50 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252078 | 0.89 | NPC1 (0.46) | BRAFMTORPIK3CAPIK3C2BMOK | |
| SCHEMBL4554179 | 0.84 | KMO (0.47) | MTORPIK3CAPIK3C2BPRKDCNPC1 | |
| SCHEMBL4562888 | 0.81 | RAB9A (0.39) | BRAFMTORPIK3CAPIK3C2BNPC1 | |
| SCHEMBL4554583 | 0.80 | PIK3CA (0.47) | MTORPIK3CAPIK3C2BPRKDCNPC1 | |
| SCHEMBL4392546 | 0.80 | PRKDC (0.43) | MTORPIK3CAPIK3C2BPRKDCKDM4E | |
| SCHEMBL4433857 | 0.78 | PRKDC (0.57) | BRAFMTORPIK3CAPIK3C2BPRKDC | |
| SCHEMBL4566064 | 0.76 | PIK3CA (0.39) | MTORPIK3CAPIK3C2BPRKDCKDM4E | |
| SCHEMBL1192386 | 0.74 | MTOR (0.51) | BRAFMTORPIK3CAPIK3C2BPRKDC | |
| SCHEMBL5109688 | 0.74 | PRKDC (0.57) | BRAFMTORPIK3CAPIK3C2BPRKDC | |
| SCHEMBL1858728 | 0.72 | NPC1 (0.51) | MTORPIK3CANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |