Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.38 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554179 | 0.84 | KMO (0.47) | PRKDCALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL4554583 | 0.84 | PIK3CA (0.47) | PRKDCALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL4555862 | 0.80 | BRAF (0.51) | PRKDCALDH1A1KDM4EPIK3CAMTOR | |
| SCHEMBL4252078 | 0.78 | NPC1 (0.46) | PIK3CAMTORPIK3R1PIK3C2BMEN1 | |
| SCHEMBL1864535 | 0.78 | SMN1; SMN2 (0.38) | ALDH3A1ALDH1A3ALDH1A1MAPK1KDM4E | |
| SCHEMBL4566064 | 0.76 | PIK3CA (0.39) | PRKDCALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL3993337 | 0.75 | PIK3CA (0.51) | PRKDCALDH3A1ALDH1A3MAPK1HSD17B10 | |
| SCHEMBL1860764 | 0.72 | NCF1 (0.45) | PRKDCALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL4565478 | 0.72 | KDM4E (0.38) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL1865304 | 0.71 | PIKFYVE (0.51) | PRKDCALDH3A1ALDH1A3ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |