Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.47 |
| ▸ | MTOR | P42345 | 6/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554179 | 0.85 | KMO (0.47) | PIK3CAMTORKDM4EALDH1A1HPGD | |
| SCHEMBL4392546 | 0.84 | PRKDC (0.43) | PIK3CAMTORPIK3CDKDM4EALDH1A1 | |
| SCHEMBL4555862 | 0.80 | BRAF (0.51) | PIK3CAMTORKDM4EALDH1A1PRKDC | |
| SCHEMBL1860764 | 0.80 | NCF1 (0.45) | PIK3CAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4252078 | 0.79 | NPC1 (0.46) | PIK3CAMTORPIK3CDJAK2PIK3CB | |
| SCHEMBL4566064 | 0.77 | PIK3CA (0.39) | PIK3CAMTORPIK3CGKDM4EALDH1A1 | |
| SCHEMBL14954840 | 0.74 | SMN1; SMN2 (0.40) | PIK3CAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4554726 | 0.73 | SMN1; SMN2 (0.38) | PIK3CAMTORKDM4EALDH1A1HPGD | |
| SCHEMBL1263031 | 0.73 | MAPT (0.54) | PIK3CAMTORPIK3CDPIK3CGJAK2 | |
| SCHEMBL4565478 | 0.72 | KDM4E (0.38) | PIK3CAKDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |