Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557277 | 0.86 | DGAT1 (0.49) | DGAT1HDAC1 | |
| SCHEMBL13930380 | 0.79 | DRD2 (0.43) | DGAT1ALDH1A1CASP1CASP7MAPT | |
| SCHEMBL3741394 | 0.66 | NPY5R (0.52) | NPY5RADRA1AKCNH2 | |
| SCHEMBL13045576 | 0.66 | NPY5R (0.52) | NPY5RADRA1AKCNH2 | |
| SCHEMBL3741390 | 0.66 | NPY5R (0.52) | NPY5RADRA1AKCNH2 | |
| SCHEMBL4452633 | 0.65 | SIGMAR1 (0.56) | SSTR5KCNH2 | |
| SCHEMBL4557249 | 0.65 | GRM5 (0.45) | NPY5RADRA1AGRM5KCNH2 | |
| SCHEMBL10146472 | 0.64 | DGAT1 (0.72) | DGAT1NPY5RADRA1AKCNH2 | |
| SCHEMBL735835 | 0.64 | NPY5R (0.47) | NPY5RADRA1AKCNH2 | |
| SCHEMBL4556993 | 0.64 | HDAC6 (0.50) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |