Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014482 | 0.92 | PDE10A (0.44) | PDE10ATRPV1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4011353 | 0.88 | PDE10A (0.55) | PDE10A | |
| SCHEMBL4017987 | 0.85 | PDE10A (0.45) | PDE10AHTR1ASLC6A2SLC6A4TRPV1 | |
| SCHEMBL4009241 | 0.82 | PDE10A (0.44) | PDE10AHTR1ASLC6A2SLC6A4TRPV1 | |
| SCHEMBL4011858 | 0.82 | PDE10A (0.44) | PDE10A | |
| SCHEMBL4009606 | 0.82 | MAPT (0.45) | PDE10AHTR1ASLC6A2SLC6A4UGCG | |
| SCHEMBL4007141 | 0.82 | PDE10A (0.42) | PDE10ATRPV1MAPTMAPK1 | |
| SCHEMBL4015332 | 0.81 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4014684 | 0.81 | PDE10A (0.56) | PDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL16992066 | 0.81 | PDE10A (0.46) | PDE10AALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |