Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HPSE | Q9Y251 | 9/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556335 | 0.90 | NPC1 (0.58) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4555052 | 0.89 | MAPT (0.44) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4448117 | 0.88 | LMNA (0.46) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4556336 | 0.86 | NPC1 (0.58) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4439131 | 0.84 | HPSE (0.49) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL2814428 | 0.82 | KMT2A (0.60) | NPC1RAB9ATP53SMN1; SMN2MEN1 | |
| SCHEMBL4439125 | 0.82 | HPSE (0.49) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4555729 | 0.81 | NTRK1 (0.52) | SMN1; SMN2MEN1KMT2ANR1H4 | |
| SCHEMBL4555050 | 0.79 | MAPT (0.45) | NPC1RAB9ATP53SMN1; SMN2HPSE | |
| SCHEMBL4556044 | 0.78 | NR1H4 (0.49) | NPC1RAB9ATP53SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134676-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Addex Pharma SA (CH) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008117175-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2008-10-02 | — | — | WO | disclosed |