Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12023132 | 0.85 | AOC3 (0.53) | HSP90AA1HSP90AB1AOC3ABCG2KDM4C | |
| SCHEMBL29240259 | 0.81 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1AOC3CYP1A2CYP1B1 | |
| SCHEMBL14302835 | 0.78 | CYP1A2 (0.51) | CYP1A2CYP1B1CYP1A1ABCG2PTGS2 | |
| SCHEMBL12023063 | 0.78 | AOC3 (0.47) | HSP90AA1HSP90AB1AOC3KDM4CCYP3A4 | |
| SCHEMBL14950291 | 0.77 | AOC3 (0.44) | HSP90AA1HSP90AB1AOC3ABCG2KDM4C | |
| SCHEMBL9036919 | 0.77 | CYP1A2 (0.39) | HSP90AA1HSP90AB1CYP1A2CYP1B1CYP1A1 | |
| SCHEMBL9695924 | 0.76 | NPC1 (0.42) | AOC3CYP1A2CYP1B1CYP1A1PTGS2 | |
| SCHEMBL27033249 | 0.72 | AOC3 (0.53) | HSP90AA1HSP90AB1AOC3ABCG2KDM4C | |
| SCHEMBL9788822 | 0.72 | HPGD (0.41) | CYP1A2CYP1B1CYP1A1NPC1RAB9A | |
| SCHEMBL13695077 | 0.71 | AOC3 (0.37) | HSP90AA1HSP90AB1AOC3CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1436191-B | Antitumor ecteinascidin derivatives | PHARMA MAR SA | 2011-09-14 | — | — | CN | disclosed |
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GILLESPIE PAUL | 2009-06-18 | — | — | US | disclosed |
| US-7524870-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | HOFFMANN-LA ROCHE INC. (US) | 2009-04-28 | — | — | US | disclosed |
| CN-100475822-C | Synthesis method for producing ecteinascidin compound | PHARMA MAR SA (ES) | 2009-04-08 | — | — | CN | disclosed |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GILLESPIE PAUL | 2006-06-08 | — | — | US | disclosed |
| CN-1211386-C | Antitumoral analogue of Et-743 | PHARMA MAR SA (ES) | 2005-07-20 | — | — | CN | disclosed |
| CN-1441805-A | Antitumoral analogue of Et-743 | PHARMA MAR SA (ES) | 2003-09-10 | — | — | CN | disclosed |
| CN-1440414-A | synthetic method for producing ecteinascidin compounds | PHARMA MAR SA (ES) | 2003-09-03 | — | — | CN | disclosed |
| CN-1436193-A | Antitumoral ecteinascidin derivs | PHARMA MAR SA (ES) | 2003-08-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, GSK3A | HSP90AA1 2641/4885HSP90AB1 2761/4885AOC3 2598/4885 |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GYS2, GYS1, GSK3A | HSP90AA1 2641/4885HSP90AB1 2761/4885AOC3 2598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.