Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853726 | 0.85 | OPRD1 (0.38) | OPRM1OPRD1OPRK1OPRL1DRD1 | |
| SCHEMBL19339149 | 0.81 | OPRD1 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL19954041 | 0.81 | OPRD1 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL383808 | 0.76 | CCR1 (0.41) | OPRM1OPRD1OPRK1OPRL1SLC22A1 | |
| SCHEMBL383177 | 0.74 | ESR2 (0.51) | SLC6A4DRD1 | |
| SCHEMBL10028305 | 0.74 | OPRL1 (0.46) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL383232 | 0.73 | OPRD1 (0.40) | OPRM1OPRD1OPRK1OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL384006 | 0.72 | OPRD1 (0.39) | OPRM1OPRD1OPRK1OPRL1KCNH2 | |
| SCHEMBL12853767 | 0.72 | DRD2 (0.47) | OPRM1DRD1DRD5 | |
| SCHEMBL16838117 | 0.69 | SLC6A3 (0.46) | OPRM1OPRD1OPRK1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073803-A1 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008044041-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |