Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | SCD | O00767 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555873 | 1.00 | HDAC1 (0.47) | HDAC1KCNH2SCDHDAC3HDAC4 | |
| SCHEMBL4556849 | 0.85 | SCD (0.48) | HDAC1SCDSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3598305 | 0.72 | UBE2T (0.60) | SMN1; SMN2ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL5638622 | 0.72 | RAB9A (0.60) | HDAC3HDAC2HDAC10HDAC6SMN1; SMN2 | |
| SCHEMBL4930304 | 0.72 | ALDH1A1 (0.66) | HDAC10SMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL7325011 | 0.71 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL4556755 | 0.71 | CNR2 (0.39) | SCDCYP3A4 | |
| SCHEMBL13930462 | 0.71 | SCD (0.53) | SCD | |
| SCHEMBL13930227 | 0.68 | TRPM8 (0.39) | HDAC1KCNH2SCDRAB9ACYP3A4 | |
| SCHEMBL6132274 | 0.65 | RAB9A (0.53) | HDAC1SMN1; SMN2ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134726-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2009-11-05 | — | — | WO | disclosed |