Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.53 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | FAP | Q12884 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405246 | 0.70 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL28170738 | 0.65 | RIPK1 (0.41) | P2RX7DPP4FAPDPP8DPP9 | |
| SCHEMBL455108 | 0.61 | SLC6A2 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8349146 | 0.61 | CTSS (0.42) | P2RX7DPP4FAPDPP8DPP9 | |
| SCHEMBL10116484 | 0.61 | CYP1A2 (0.33) | P2RX7 | |
| SCHEMBL1527383 | 0.60 | USP2 (0.51) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL13687604 | 0.59 | RIPK1 (0.43) | P2RX7RIPK1 | |
| SCHEMBL2564601 | 0.58 | CES2 (0.43) | P2RX7DPP4FAPDPP8DPP9 | |
| SCHEMBL2151373 | 0.58 | CES2 (0.43) | P2RX7DPP4FAPDPP8DPP9 | |
| SCHEMBL3718076 | 0.58 | DPP4 (0.43) | DPP4FAPDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074519-A1 | COMBINATIONS OF PYRAZOLYL OR ISOXAZOLYL P2X7 MODULATORS WITH FURTHER THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |