Sugi Predict

Sugi Predict / Compounds / SCHEMBL4558134

SCHEMBL4558134

SCHEMBL4558134

OC(CNCc1ccccc1)[C@@H]1CCc2cc(F)ccc2O1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 11/20 0.78
▸ DRD3 P35462 10/20 0.78
▸ HTR1A P08908 2/20 0.78
▸ HTR2A P28223 2/20 0.78
▸ HTR2C P28335 2/20 0.78
▸ MLNR O43193 1/20 0.78
▸ ADRB2 P07550 1/20 0.78
▸ ADRB1 P08588 1/20 0.78
▸ ADRA2A P08913 1/20 0.78
▸ ADORA3 P0DMS8 1/20 0.78
▸ CHRM1 P11229 1/20 0.78
▸ KCNE1 P15382 1/20 0.78
▸ ADRA2B P18089 1/20 0.78
▸ ADRA2C P18825 1/20 0.78
▸ CNR1 P21554 1/20 0.78
▸ SLC6A2 P23975 1/20 0.78
▸ NPY1R P25929 1/20 0.78
▸ AVPR2 P30518 1/20 0.78
▸ SLC6A4 P31645 1/20 0.78
▸ ADRA1A P35348 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2258387 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL2283840 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL1737105 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL2281287 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL2281292 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL30080992 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL4459884 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL2555127 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL2289517 1.00 DRD2 (0.78) DRD2DRD3HTR1AHTR2AHTR2C
SCHEMBL23940707 0.89 DRD2 (0.65) DRD2DRD3HTR1AHTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3974419-A2 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) 2022-03-30 — — EP claimed
US-20220056003-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2022-02-24 — — US claimed
US-20200102282-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2020-04-02 — — US claimed
US-20180141926-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2018-05-24 — — US claimed
EP-3299364-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) 2018-03-28 — — EP claimed
CN-101553485-A Process for preparing nebivolol ZACH SYSTEM SPA (IT) 2009-10-07 — — CN claimed
US-12466802-B2 Nebivolol synthesis method and intermediate compound thereof ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2025-11-11 — — US disclosed
EP-3974419-A2 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) 2022-03-30 — — EP disclosed
US-20220056003-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2022-02-24 — — US disclosed
EP-3299364-B1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN) 2021-10-20 — — EP disclosed
US-11142512-B2 Nebivolol synthesis method and intermediate compound thereof ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2021-10-12 — — US disclosed
EP-3405467-B1 PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL MENARINI INT OPERATIONS LUXEMBOURG SA (LU) 2021-08-04 — — EP disclosed
US-20200102282-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) 2020-04-02 — — US disclosed
EP-3299364-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) 2018-03-28 — — EP disclosed
CN-101541791-B Process for preparing nebivolol ZACH SYSTEM SPA 2014-01-29 — — CN disclosed
CN-103087028-A Process for preparing nebivolol ZACH SYSTEM SPA 2013-05-08 — — CN disclosed
CN-101553485-B Process for preparing nebivolol ZACH SYSTEM SPA 2013-02-06 — — CN disclosed
CN-101553485-A Process for preparing nebivolol ZACH SYSTEM SPA (IT) 2009-10-07 — — CN disclosed
EP-2102196-A1 PROCESS FOR PREPARING NEBIVOLOL ZaCh System S.p.A. (IT) 2009-09-23 — — EP disclosed
WO-2008064826-A1 PROCESS FOR PREPARING NEBIVOLOL ZACH SYSTEM S.P.A. (IT) 2008-06-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12466802-B2 Nebivolol synthesis method and intermediate compound thereof CYP4A11, CYP11B2, CYP11B1 DRD2 222/4885DRD3 274/4885HTR1A 1267/4885
US-20200102282-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF CYP4A11, CYP11B2, ADRB1 DRD2 205/4885DRD3 237/4885HTR1A 1318/4885
US-11142512-B2 Nebivolol synthesis method and intermediate compound thereof CYP4A11, CYP11B2, ADRB1 DRD2 205/4885DRD3 237/4885HTR1A 1318/4885
US-20220056003-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF CYP4A11, CYP11B2, CYP11B1 DRD2 222/4885DRD3 274/4885HTR1A 1267/4885
US-20180141926-A1 NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF CYP4A11, CYP11B2, ADRB1 DRD2 205/4885DRD3 237/4885HTR1A 1318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.