Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.78 |
| ▸ | DRD3 | P35462 | 10/20 | 0.78 |
| ▸ | HTR1A | P08908 | 2/20 | 0.78 |
| ▸ | HTR2A | P28223 | 2/20 | 0.78 |
| ▸ | HTR2C | P28335 | 2/20 | 0.78 |
| ▸ | MLNR | O43193 | 1/20 | 0.78 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.78 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.78 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.78 |
| ▸ | CNR1 | P21554 | 1/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.78 |
| ▸ | NPY1R | P25929 | 1/20 | 0.78 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2258387 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL2283840 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL4558134 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL1737105 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL2281292 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL30080992 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL4459884 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL2555127 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL2289517 | 1.00 | DRD2 (0.78) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL23940707 | 0.89 | DRD2 (0.65) | DRD2DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974419-A2 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-03-30 | — | — | EP | disclosed |
| US-20220056003-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2022-02-24 | — | — | US | disclosed |
| EP-3299364-B1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN) | 2021-10-20 | — | — | EP | disclosed |
| US-11142512-B2 | Nebivolol synthesis method and intermediate compound thereof | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| EP-3405467-B1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | MENARINI INT OPERATIONS LUXEMBOURG SA (LU) | 2021-08-04 | — | — | EP | disclosed |
| US-20200102282-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2020-04-02 | — | — | US | disclosed |
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2019-08-27 | — | — | US | disclosed |
| US-20190031636-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2019-01-31 | — | — | US | disclosed |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| EP-2528905-B1 | PROCESS FOR THE PREPARATION OF NEBIVOLOL | CORDEN PHARMA COLORADO INC (US) | 2015-10-07 | — | — | EP | disclosed |
| CN-101541791-B | Process for preparing nebivolol | ZACH SYSTEM SPA | 2014-01-29 | — | — | CN | disclosed |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMA INTERNATIONAL GMBH | 2013-01-03 | — | — | US | disclosed |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMA INTERNATIONAL GMBH | 2013-01-03 | — | — | US | disclosed |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMA INTERNATIONAL GMBH | 2013-01-03 | — | — | US | disclosed |
| EP-2528905-A1 | METHOD FOR PRODUCING NEBIVOLOL | Corden Pharmachem GmbH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-8003810-B2 | Process for preparing Nebivolol | ZACH SYSTEM S.P.A. (IT) | 2011-08-23 | — | — | US | disclosed |
| WO-2011091968-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMACHEM GMBH (DE) | 2011-08-04 | — | — | WO | disclosed |
| WO-2011091968-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMACHEM GMBH (DE) | 2011-08-04 | — | — | WO | disclosed |
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ADRB1, ADRB2, ADRA1B | DRD2 124/4885DRD3 100/4885HTR1A 494/4885 |
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | ADRB3, ADRB2, ADRB1 | DRD2 388/4885DRD3 270/4885HTR1A 694/4885 |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | ADRA2B, ADRA1B, ADRB2 | DRD2 33/4885DRD3 84/4885HTR1A 1114/4885 |
| US-20200102282-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, ADRB1 | DRD2 205/4885DRD3 237/4885HTR1A 1318/4885 |
| US-11142512-B2 | Nebivolol synthesis method and intermediate compound thereof | CYP4A11, CYP11B2, ADRB1 | DRD2 205/4885DRD3 237/4885HTR1A 1318/4885 |
| US-20220056003-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, CYP11B1 | DRD2 222/4885DRD3 274/4885HTR1A 1267/4885 |
| US-20190031636-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | ADRB3, ADRB2, ADRB1 | DRD2 388/4885DRD3 270/4885HTR1A 694/4885 |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, ADRB1 | DRD2 205/4885DRD3 237/4885HTR1A 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.